Two new preprints this week! Big congratulations to first authors Eliseos J Mucaki and Noor Rizvi, respectively and collaborators Mike Hallett and Eileen Rakovitch
First, we developed novel generative modeling approaches to address the unique challenges of working with FFPE material, enabling more reliable transcriptomic analyses from these challenging samples (Mucaki et al., bioRxiv 2025).
Our new manuscript covering a new FFPE-based RNA-seq methodology. Led by John Mucaki and with our collaborators Vanessa Dumeaux at Western and Eileen Rakovitch at Sunnybrook. www.biorxiv.org/content/10.1...
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— Mike Hallett (@hallettmiket.bsky.social) February 28, 2025 at 6:42 PM
Second, we have characterized the DNA mutational landscape of DCIS, identifying specific mutated genes associated with early recurrence, particularly in the context of radiotherapy (Rizvi et al. medRxiv 2025).
🧵 1/11 Excited to share our latest work on ductal carcinoma in situ (DCIS) genomics! We performed comprehensive genomic analysis of pure DCIS to better understand disease prognosis and treatment response. medrxiv.org/cgi/content/... #BreastCancer #DCIS #Cancer #Genomics #PrecisionMedicine
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— Vanessa Dumeaux 🇨🇦 (@vdumeaux.bsky.social) March 6, 2025 at 11:36 AM