From single cells
to patients —
immunity,
tumors,
microbiomes.
We apply single-cell and computational genomics to two connected problems: the crosstalk between a patient's immune system and their breast tumor, and the functional variation within human microbial communities — from gut microbiomes to fungal pathogens.
We profile blood and tumor at single-cell resolution to map the immune–tumor crosstalk, and build molecular predictors of recurrence and treatment response across invasive breast cancer and DCIS.
Single-cell and computational approaches to read microbial life across scales — from individual fungal cells, to multi-species interactions, to the functional configurations that organize the human gut microbiome.
Integrating -omics with epidemiology so complex real-life data can inform causation, not just correlation. We build the tools — MIxT, PREFFECT, Candescence — that let the rest of the lab do its work.