From single cells
to patients —
immunity,
tumors,
microbiomes.
Our lab applies single-cell and computational genomics to two main questions: how a patient's immune system interacts with their breast tumor, and how function varies within human microbial communities such as the gut microbiome and fungal pathogens.
We profile blood and tumor at single-cell resolution to map the immune–tumor crosstalk, and build molecular predictors of recurrence and treatment response across invasive breast cancer and DCIS.
Single-cell and computational approaches to read microbial life across scales: individual fungal cells, multi-species interactions, and the functional configurations that organize the human gut microbiome.
We combine -omics with epidemiology to push complex real-world data toward questions of causation, not just correlation. The tools we've built along the way, such as MIxT, PREFFECT, and Candescence, support the rest of the lab's work.