§ Research programme

The tumor in its host.
The microbe in its community.

We profile blood, tumors, and microbes from single cells to whole communities, and build the computational methods that turn those signals into predictions of treatment response and disease progression.

01 / 03
Immunity × Tumor
breast cancerin situ diseasesystemic immunityblood transcriptomics

We profile blood and tumor at single-cell resolution to map the immune–tumor crosstalk, and build molecular predictors of recurrence and treatment response across invasive and in situ breast cancer.

Methods — bulk + scRNA-seq · WES · spatial transcriptomics
02 / 03
Microbial Communities
gut microbiomeC. albicansfunctional archetypesscRNA-seq

Single-cell and computational approaches to study microbial life across scales: individual fungal cells, multi-species interactions, and recurring functional states in the human gut microbiome.

Methods — microbial scRNA-seq · deep learning · archetypal analysis
03 / 03
Computational Methods
systems epidemiologyFFPE RNA-seqmulti-tissue integration

We develop statistical and machine-learning methods for -omics data collected in human cohorts and clinical samples. MIxT, PREFFECT, Candescence and deep-fMC came out of this work.

Methods — probabilistic models · graph neural nets · R / Python packages
Funding sources
NSERCCIHRCancer Research SocietyVector InstituteCCSRIBreast Cancer CanadaVerspeeten Family Cancer CentreSchulich Medicine & DentistryERC