Our research focuses on understanding the molecular aspects of human physiology and disease incidence/prognosis in the context of the individual (e.g. exposures & lifestyle, immune response, microbiome). This includes (1) the development of computational and genomic methods to analyze microbial systems under various conditions, including drug treatments and health states, and (2) the identification of tumoral, systemic, and gut microbial markers that can predict cancer therapy outcomes.